Search on: FORMATE-TETRAHYDROFOLATE LIGASE 
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Descriptor English:   Formate-Tetrahydrofolate Ligase 
Descriptor Spanish:   Formiato-Tetrahidrofolato Ligasa 
Descriptor Portuguese:   Formiato-Tetra-Hidrofolato Ligase 
Synonyms English:   Formyltetrahydrofolate Synthetase
Formate Tetrahydrofolate Ligase
Formylase, Tetrahydrofolate
Ligase, Formate-Tetrahydrofolate
Synthetase, Formyltetrahydrofolate
Tetrahydrofolate Formylase  
Tree Number:   D08.811.464.259.550
Definition English:   A carbon-nitrogen ligase that catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate in the presence of ATP. In higher eukaryotes the enzyme also contains METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP+) and METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE activity. 
See Related English:   Methenyltetrahydrofolate Cyclohydrolase
Methylenetetrahydrofolate Dehydrogenase (NADP)
 
History Note English:   98(75) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   5709 
Unique Identifier:   D005574 

Occurrence in VHL:
 

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